Publications

The publications menu item above now provides a list of publications related to the repository. This is an ongoing project where we use a variety of methods to build the list, including mining publications that reference various IDs such as Cell Line IDs and Biomaterials IDs from the repository. For some cell lines, the catalog application provides a link to publications related to only that line. See, for example, ND29492.

Recently Added Lines

Visit this link to view the most recently updated subjects in the catalog.

February 22, 2021

NHCDR iPSC Line Approved for Use in Clinical Trial

An important advancement with human induced pluripotent stem cells (iPSCs) was announced this month. The GMP iPSC cell line distributed by Infinity BiologiX as part of the NINDS Human Cell and Data Repository (NHCDR) was approved for use in a clinical trial in Germany. This is the first time that engineered heart muscle (EHM) from iPSCs will be used to treat patients with heart failure. Read the full announcement here.

Testing ninds1.

November 7, 2020

We added a new disease collection, Lewy Body Dementia, as part of The PDBP Project, one of our collaborative projects. To view subjects in this collection, click the Lewy Body Dementia button at the top of the catalog app in the section Filter Subjects by Disease Collection.

June 30, 2019

Fourteen fibroblasts were recently added, mainly to our Dystonia collection

Visit this link to view the most recently updated subjects in the catalog.

May 22, 2019

Seven iPSCs were added to various collections including LEFFTDS, Parkinsonism and HD

Visit this link to view the most recently updated subjects in the catalog.

May 13, 2019

Six fibroblasts were added to the Dystonia collection

Visit this link to view the most recently updated subjects in the catalog.

May 1, 2019

New lines added

We added 15 new lines in April. Visit this link to view the most recently updated subjects in the catalog. To view individual lines for a subject, click on a subject in the main table and go to the detailed view of that subject below, then click on the "Cell Lines" tab.

April 1, 2019

New line added

Today we iPSC BID00476 in both the Huntington's and Controls collection. Visit this link to view the most recently updated subjects and lines in the catalog. 

March 5, 2019

New lines added

Today we added 2 new biomaterials: iPSC BID00457 in the ALS collection and BID00458 in the Parkinsonism collection. Visit this link to view the most recently updated subjects and lines in the catalog. 

February 12, 2019

New Certificates of Assurance added

Today we COAs for 5 lines in Parkinsonism, FTD and ALS collections: BID00421, BID00422, BID00423, BID00424 and BID00425. Visit this link to view the most recently updated subjects and lines in the catalog. 

February 7, 2019

Research grade GMP line added to the catalog

An issue has arisen regarding the research grade cell line (ND50038) made by Lonza that RUCDR is distributing as part of the NINDS NHCDR collection.  Recently it was discovered that this line contains a duplication in chromosome 20 in the BCL2L2 gene.  It has previously been shown that mutations in BCL2L2 can confer a growth advantage in culture.   

Further analysis has confirmed that while this mutation is present in the research grade line, this duplication is not present in the GMP grade line (ND50039).  In order to continue to provide a non-GMP version of this cell line, RUCDR has thawed, expanded, banked and performed extensive QC on a vial from the GMP grade stocks under non-GMP conditions. This new line (NH50191) has been shown to be karyotypically normal, capable of differentiating into all 3 germ layers, and expresses expected stemness markers.  In addition to these tests specific to stemness and pluripotency, the cell line has also been tested for identity, sterility (including mycoplasma) and viability.  To ensure that the new cell line is free from duplications in the BCL2L2 gene and any other significant deletions or duplications it has been tested by PCR for CNVs in the BLC2L2 gene and by CNV array as a means to broadly survey the genome.  Both the PCR and CNV array confirm that the new line does not carry the BLC2L2 duplication and can be provided upon request.  

This cell line is now available for purchase on the NHCDR web catalog as biomaterial BID00456 (under parent cell line NH50191).  If you have received a vial of the research grade cell line before this issue was discovered in October 2018, you can contact Dr. Jennifer Moore (moore@biology.rutgers.edu) to obtain a replacement vial.  Any other questions related to this issue can also be addressed to Dr. Moore. 

February 2, 2019

You can now specify the number of vials when ordering

When you add a line to the cart, you can now use up and down arrows to adjust the number of vials you would like. See this page for more information.

January 16, 2019

Added 8 iPSCs for Parkinsonism and ALS

This includes 5 new edited lines. Visit this link to view the most recently updated subjects and lines in the catalog. Click the "Edited iPSCs" button at the top to show subjects with edited lines.

January 11, 2019

Several Dystonia updates

Several subjects were updated with new clinical and genetic data. Visit this link to view the most recently updated subjects and lines in the catalog.

November 28, 2018

Updated genetic variant data for LEFFTDS subjects

Visit this link to view the most recently updated subjects and lines in the catalog application. Click the LEFFTDS button at the top to show only subjects in the LEFFTDS project.

February 5, 2018

CRISPR/Cas9 Edited Lines

We have begun adding CRIPR/Cas9 edited iPSCs to the catalog. To view subjects with edited iPSCs, click the "Edited iPSCs" button at the top of the page under "Filter by Subjects with Cell Types". Visit this link to view the most recently updated subjects and lines in the catalog application.

September 23, 2017

Added new data for the The NeuroLINCS Project: 18 new iPSCS added for 14 new subjects and 3 existing subjects. Visit this link to view the most recently updated subjects and lines in the catalog.

February 8, 2017

Six new iPSCs were added to the catalog and 2 existing lines were regrown at RUCDR. Visit this link to view the most recently updated subjects and lines in the catalog.

December 6, 2016

Six new iPSCs were added to the catalog, including the Control, Frontotemporal Degeneration and Parkinsonism collections. Visit this link to view the most recently updated subjects and lines in the catalog.

October 25, 2016

Today we added 8 new iPSCs to the Parkinsonism collection. Visit this link to view the most recently updated subjects and lines in the catalog.

October 9, 2016

We recently updated some iPSCs in the catalog including 9 new lines. These are FCLs that were reprogrammed at RUCDR.   Visit this link to view the most recently updated subjects and lines in the catalog application.

September 20, 2016

We recently added 2 iPSCs to the catalog as part of the new GMP Grade Project. Click the link to view the most recently updated subjects and lines in the catalog application. You can also click the "GMP Grade Project" button at the top of the catalog to select only subjects with GMP grade lines. See our FAQ for more information about the GMP lines.

August 30, 2016

We recently added 6 iPSCs to the catalog. These are re-grows of existing lines. The re-grows were performed at RUCDR. Click the link to view the most recently updated subjects and lines in the catalog application.

August 18, 2016

We added 14 new subjects and iPSCs to the catalog. These are a part of the new NIH RMP project. You can use the NIH RMP filter at the top to view these new subjects. Click the link to view the most recently updated subjects and lines in the catalog application.

July 17, 2016

We added six new iPSCs to the catalog. Three iPSCs were added for each of the following subjects: NDS00227 (Parkinsonism) and NDS00172 (Frontotemporal Degeneration). Click the link to view the most recently updated subjects and lines in the catalog application.